Fentanyl Citrate Injection, USP
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چکیده
Fentanyl Citrate Injection, USP is a potent o p i o i d ag o nis t . Each milliliter of solution contains fentanyl citrate equivalent to 50 mcg of fentanyl base, adjusted to pH 4.0 to 7.5 with sodium hydroxide. Fentanyl citrate is chemically identified as N-(1-phenethyl-4-piperidyl) propionanilide citrate (1:1) with a molecular weight of 528.60. The empirical formula is C22H28N2O • CH8O7. The structural formula of fentanyl citrate is:
منابع مشابه
Development and validation of an HPLC assay for fentanyl and related substances in fentanyl citrate injection, USP.
The stability indicating properties of the USP method for the assay of fentanyl in fentanyl citrate injection were evaluated [1] by analyzing fentanyl drug substance and product after acid, hydrogen peroxide, heat, and light treatment. N-phenyl-N-(4-piperidinyl)propionamide (PPA), which is a known degradation product/process impurity of fentanyl, was not adequately resolved from the fentanyl pe...
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Fentanyl citrate analgesia attenuates the excess nitrogen excretion in the urine and glucose production induced by trauma. On the other hand, intracerebroventricular injection of morphine stimulates excretion of stress hormones, such as catecholamines and corticosterone. Furthermore, morphine levels in the brain are increased during fasting and sepsis. The aims of this study were to determine w...
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Shirouzu, Yuichirou, Kazuo Shirouzu, and Shogo Yoshida. Effect of fentanyl on morphine levels in the brain in rats receiving intracerebroventricular injection of TNF-a. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E635–E640, 1998.—Fentanyl citrate analgesia attenuates the excess nitrogen excretion in the urine and glucose production induced by trauma. On the other hand, intracerebroventricular ...
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